Acelex, a commonly prescribed antidepressant, has been in use for a number of years for its effectiveness in treating depression. Although there are different antidepressants available in different forms (e.g., fluoxetine, paroxetine), one of the most common forms is aceclofenac (Prozac). While Prozac works by inhibiting the reuptake of serotonin, it does not address the underlying issue of serotonin imbalance.
The purpose of this study was to compare the efficacy of aceclofenac, an antidepressant, and placebo in treating depression in patients receiving a treatment program for major depressive disorder (MDD).
This was a randomized, double-blind, controlled trial conducted at a tertiary hospital in Scotland. Patients were treated with an antidepressant and placebo in one of two phases: phase 1, a 5-day treatment period; or phase 2, a 30-day treatment period.
In phase 1, patients had to undergo a brief, placebo-controlled treatment period. Patients were instructed to take one capsule of aceclofenac, three times daily, and then receive a maintenance dose of 30 mg of aceclofenac. At the end of treatment, the patients had to have an evaluation of their overall mood.
The primary outcome of interest was the response to the treatment period. Secondary outcomes were the clinical course, depression symptoms, and suicidal ideation, and treatment effect.
Aceclofenac was randomized to either placebo or an SSRI (fluoxetine) at a dose of 60 mg per day (one dose). The primary outcome of interest was the response to treatment.
The patients were randomized to either aceclofenac (n = 18) or placebo (n = 18).
Patients were randomly assigned to the aceclofenac group or the placebo group. The study was terminated prematurely because of a serious adverse reaction that could not be controlled. Patients in the aceclofenac group received an SSRI (posterior) to determine their response to the treatment period.
As the primary outcome of interest, the mean (range) change from baseline in the Hamilton Depression Rating Scale (HAM-D) score was compared between the two groups (group 1: placebo, n = 18; group 2: aceclofenac, n = 18; group 3: placebo, n = 18). The primary endpoint of interest was the change from baseline in HAM-D score from baseline to treatment. The secondary endpoints were the HAM-D score change from baseline to treatment.
The mean change from baseline in the HAM-D score from baseline to treatment were compared between the two groups. The mean change from baseline in the HAM-D score from baseline to treatment was significantly greater in the aceclofenac group than in the placebo group. The mean change from baseline in the HAM-D score from baseline to treatment was also significantly greater in the aceclofenac group than in the placebo group.
The primary outcome of interest was the change from baseline in the HAM-D score from baseline to treatment. Secondary outcomes were the HAM-D score change from baseline to treatment, the HAM-D score change from baseline to treatment, and the overall HAM-D score change from baseline to treatment.
The treatment effect was assessed using the change from baseline in the HAM-D score from baseline to treatment (from baseline to treatment):Treatment effect:Change from baseline Change from baseline to treatment.
Patients who completed the treatment period were excluded from the analysis.
The secondary outcomes were the HAM-D score change from baseline to treatment.
Celexa is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression and anxiety disorders in the treatment of major depressive disorder (MDD). Celexa works by increasing the levels of serotonin and norepinephrine in the brain.
Celexa is the only medication that has been approved for the treatment of depression and anxiety, as well as other conditions, including obsessive-compulsive disorder (OCD).
Celexa is taken once a day, in doses of 10 mg to 20 mg per day. The maximum dose prescribed for this condition is 20 mg per day and should not be taken more than once per day. In some cases, Celexa may cause more side effects, such as nausea, dry mouth, constipation, dry mouth, dizziness, or headache. It is important to follow the prescribed dosage and the doctor’s instructions. In the United States, the dosage of Celexa is 40 mg per day, which should be gradually increased to the maximum dosage of 80 mg per day (see “How to take Celexa?”).
If your doctor has prescribed Celexa for you, follow the directions on your prescription label carefully. It is important to complete the full course of treatment as prescribed by your doctor to ensure that the medication is working as intended. Celexa can be taken with or without food, but it is best to take it at a fixed time each day.
Celexa is not intended for immediate relief of depression, anxiety, or any other mental illness.
Celexa is not for treating a specific type of depression or any other condition. If you experience a mental illness such as depression, anxiety, or any other mental illness, consult with your doctor before taking the medication for any condition.
Celexa may increase the risk of side effects such as dry mouth, dizziness, constipation, dry mouth, nausea, and dizziness.
The side effects of Celexa (Celexa) include:
• Nausea• Blurred vision• Dizziness• Headache• Insomnia• Dry mouth• Fatigue• Headaches• Sleepiness• Weight changes
It is important to take Celexa at the same time each day and to complete the full course of treatment as prescribed by your doctor. Continue to take Celexa even if you feel well. Stopping Celexa suddenly can cause serious side effects. It is important to talk to your doctor if you experience any unusual symptoms while taking Celexa.
Tell your doctor if you are pregnant or breastfeeding. Celexa passes into breast milk and may harm a nursing baby. Be sure to take Celexa exactly as prescribed by your doctor. Celexa may be affected by certain medications, such as antidepressants, anti-anxiety medications, or heart rhythm medications.
Celexa has been shown to cause some side effects. Talk to your health care provider if these reactions do not disappear within a few days or become severe.
Common side effects reported from Celexa use:
This is not a complete list of adverse reactions. If you experience difficulty breathing, unusual bleeding or bruising, chest pain, a skin rash, hives, fever, joint pain, muscle stiffness, swelling, seizures, hallucinations, hoarseness, or changes in your heart rate while taking Celexa, seek medical attention immediately.
Antidepressant drugs like Celexa increase the risk of suicidal thoughts or behaviors, so patients taking Celexa should be monitored for the emergence or worsening of depression, suicidal thoughts or behaviors, or unusual changes in mood or behavior.
As with all prescription medications, inform the prescribing doctor about any medical conditions you have been diagnosed with and any medications or supplements you currently take before starting treatment with Celexa. Celexa can interact with other medicines and substances, causing potentially serious side effects. Before beginning treatment with Celexa, let your doctor know if you are pregnant or are planning on becoming pregnant.
How eCelexa WorksCelexa increases the amount of citalopram (citalopram with or without the active ingredient) in the body. This action RSSed medication is sent to your smart card and placed into the slow-release tablet. Celexa contains the same active ingredient as citalopram, citalopram. Celexa works by changing the way certain chemicals in the brain work, which may help treat depression.
As the name suggests, Celexa can change the way some neurotransmitters in the brain work. The result is changed how the brain processes information. This can be helpful for people who have trouble keeping track of their thoughts or emotions.
In some cases, Celexa can also cause nausea, vomiting, diarrhea, gas, or blood in the stool. If you experience severe nausea, chest pain, a skin rash, hives, fever, joint pain, muscle stiffness, swelling, hoarseness, swelling, thirst, heartburn,selves a skin rash, fever, weakness, pain, or excited muscles, contact your doctor.
Kelp is a supplement that contains the same active ingredient as citalopram. Kelp works by changing how certain chemicals in the brain work, which may help treat depression.
What the community has to sayBe sure to balance your intake of kelp with that of other supplements before starting Celexa.
Be proactiveBe especially careful when taking supplements that contain alcohol, as they can cause increased drowsiness and dizziness. Additionally, kelp should not be used with other antidepressant drugs, as the combination can cause serious side effects.
Discuss your side effects with your doctor as needed, even if your symptoms improve before starting treatment with Celexa.
Celexa has been shown to increase the chances of developing depression, so patients taking Celexa should be monitored for the emergence or worsening of depression, suicidal thoughts or behaviors, or unusual changes in mood or behavior.
References1. Food and Drug Administration. Celexa (citalopram) [adeshic] [online]. Bethesda, Maryland: FDA; 2022.
2. GaBI; 2019;7:e00130-21. doi:
3. GaBI; 2024;30:1-8.
Alternate Name:CeleXA
Description:Celexa is prescribed for the treatment of depression. The generic version of Celexa is Citalopram. On average Celexa is priced at about $325 for a supply of 30, 20 mg tablets. Luckily, you can use our LowerMyRx savings offer to receive a Celexa discount of up to 80% off the retail price at participating pharmacies near you.
Dosage Form:Tablet
Administration Route:By mouth
Drug Class:Antidepressant
Generic Available:Yes
Strength:20 MG
Warnings:Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, glaucoma, electrolyte imbalance, heart problems, sexual problems, or a seizure disorder. Tell your doctor if you or anyone in your family has a bipolar disorder, heart rhythm problem (including QT prolongation or a slow heartbeat), or a recent heart attack. For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts. This medicine may cause the following problems: Heart rhythm problemsSerotonin syndrome (may be life threatening when used with certain other medicines)Increased risk of bleeding problemsSlow growth in childrenSexual problems This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Keep all medicine out of the reach of children. Never share your medicine with anyone. Thoughts of hurting yourself or others, unusual behavior Unusual bleeding or bruising
Food Warnings:Do not use this medicine if you are using pimozide. Do not use this medicine together with an MAO inhibitor (MAOI) or if you have used an MAOI within the past 14 days. Do not take an MAOI for at least 14 days after you stop this medicine., Do not drink alcohol while you are using this medicine., This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you., Your doctor may want to monitor your child's weight and height, because this medicine may cause decreased appetite and weight loss in children., Some medicines can affect how citalopram works. Tell your doctor if you are using the following: Buspirone, carbamazepine, chlorpromazine, cimetidine, fentanyl, gatifloxacin, imipramine, itraconazole, ketoconazole, levomethadyl, lithium, methadone, meperidine, moxifloxacin, omeprazole, pentamidine, St John's wort, thioridazine, tramadol, tryptophan supplementsAmphetaminesBlood thinner (including warfarin)Diuretic (water pill)Medicine for heart rhythm problems (including amiodarone, procainamide, quinidine, sotalol)NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Triptan medicine to treat migraine headaches (including sumatriptan), Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely., Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments., Keep all medicine out of the reach of children.
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Note: After consulting with your doctor, it is possible for elderly patients to experience side effects from starting a new medicine. Tell your doctor if you are pregnant or breastfeeding or if you have difficulty swallowing food.
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